Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients

N/ACompletedNCT02077231

Xiaodong Zhou30 enrolled

Overview

Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Primary Open-angle Glaucoma

Interventions

Vitamin ADRUG

use one drop in the eye

carbomer eye gelDRUG

use one drop in the eye

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year. Exclusion Criteria: 1. any systemic diseases which may cause ocular damage; 2. previous ocular trauma or surgery; 3. contact lens wear history in previous 6 months; 4. application of any artificial tears 3 months ago; 5. allergic to any of the drugs we used during examination.

Outcomes

Primary Outcomes

change of the density of conjunctival goblet cells

Time frame: change from Baseline in goblet cell density at 6 months

Secondary Outcomes

tear film parameters changes in patients

Time frame: change from baseline in TBUT and Schirmer test at 6 months

changes of ocular irritation in patients

Time frame: change from baseline in OSDI scores at 6 months

Data from ClinicalTrials.gov

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