Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
24
Then participants will receive stimulation for 20 minutes.
Chang Gung University
Taoyuan District, Taiwan
Motor evoked potential
measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.
Time frame: Baseline
Intracortical inhibition, ICI
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Time frame: Baseline,2 hours, 2.5 hours,and 3 hours
intracortical facilitation, ICF
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Time frame: Baseline,Baseline,2 hours, 2.5 hours,and 3 hours
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