Volontary Inspiratory Muscles Measures Compared With Phrenic Nerves Magnetic Stimulations Measures

N/ATerminatedNCT02078050

Centre d'Investigation Clinique et Technologique 80554 enrolled

Overview

Respiratory failure is the main death cause in neuromuscular diseases. Non-invasive and volitional measures of inspiratory muscles strength include the nasal pressure with an occluded nostril (Psnip) and the maximal inspiratory pressure (PImax). Unfortunately, volitional maneuvers depend of patient effort. The aim of this research is to validate a non-invasive and non-volitional technique to evaluate diaphragm strength at neuromuscular diseases patients. The methodology consists to add to PImax and Psnip measures 5 phrenic nerves magnetical stimulation maneuvers (Pstim).Stimulations will be realize at 3 inspiratory pression levels (0, -1 cm H2O and -5 cm H2O).

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Neuromuscular Diseases Respiratory Failure

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years old and more men or women * neuromuscular diseases * Pimax and Snip evaluation Indication Exclusion Criteria: * pregnant women * Usual contre-indications for nuclear magnetic resonance

Locations (1)

Hopital R. Poincaré

Garches, France

Outcomes

Primary Outcomes

Magnetic stimulation pressure measure (Pstim), according to 3 conditions : Pstime, Pstim-5 and Pstim-1 (measured in cmH20). The condition which is most correlated with maximal inspiratory pressure (Pimax or Psnip) is selected.

Time frame: 10 minutes

Data from ClinicalTrials.gov

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