The purpose of this study is to examine the effect on blood pressure of 3 months of treatment with continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA). Hypothesis: 1. Central 24-h blood pressure (BP) monitoring hedges day fluctuations in blood pressure more accurately than peripheral 24-h BP monitoring, because the measurement is painless and does not interfere with the patient / subject's activities during the daytime or nighttime sleep. 2. Blood pressure is elevated in patients with OSA and falls during treatment with CPAP. 3\. The renal treatment of salt and water is abnormal in OSA, improved during treatment with CPAP. 4\. Quality of life improves during treatment with CPAP
Approximately 20 patients with hypertension and moderate to severe OSA are treated with CPAP 3 months to examine the treatment effect on blood pressure throughout the day, but especially nocturnal, renal treatment of salt and water, and quality of life. Before and after 3 months of CPAP treatment is made central and peripheral 24-h ambulatory blood pressure monitoring, 24-h urine collection and blood samples.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
3 months of CPAP treatment
Department of Medical Research and Medicine, Holstebro Regional Hospital
Holstebro, Holstebro, Denmark
RECRUITINGdifference in systolic peripheral BP at night
The difference in systolic BP at night by peripheral BP days before and after 3 months of treatment of OSA with CPAP in patients with hypertension.
Time frame: 3 months
Difference i central systolic BP
The difference in systolic BP at night in central BP days before and after 3 months of treatment of OSA with CPAP in patients with hypertension.
Time frame: 3 months
Difference i BP throughout the day
The difference in systolic BP and diastolic BP throughout the day, in the daytime and in nighttime between measurements with peripheral and central 24-h blood pressure monitoring before and after 3 months of treatment with CPAP.
Time frame: 3 months
Correlation between degree of OSA and kidney function on effect of treatment
The correlation between the treatment effect on blood pressure levels on the one hand and the severity of OSA prior to initiation of treatment and renal function as measured by estimated glomerular filtration rate (eGFR) on the other.
Time frame: 3 months
urine auquaporine2 (u-AQP2) and urine epithelial Natrium channel (u-ENaC)
Changes in U-AQP2 and u-ENaC in 24-h urine samples before and after 3 month of treatment.
Time frame: 3 months
Plasma renin concentration (PRC), plasma angiotensin II (p-AngII), plasma aldosterone (p-Aldo), plasma vasopressin (P-AVP) and plasma endothelin (p-endothelin).
Changes in PRC, p-AngII, p-Aldo. P-AVP and p-endothelin in blood samples before and after 3 month of treatment.
Time frame: 3 months
Quality of life
Changes in the quality of life before and after treatment of OSA with CPAP.
Time frame: 3 months
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