To compare the efficacy and safety of clopidogrel monotherapy versus aspirin plus P2Y12 antagonist following 3-month of DAPT in patients undergoing PCI with DES.
This trial is a prospective, randomized, multi-center, open label, noninferiority trial. Patients undergoing PCI with DES will be eligible. After successful PCI with DES, all eligible patients will be randomized either to clopidogrel monotherapy or to aspirin plus P2Y12 antagonist following 3-month of DAPT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
3,000
Cardiac and Vascular Center; Samsung Medical Center
Seoul, South Korea
A composite of death, myocardial infarction, or cerebrovascular events
12 months after the index procedure
Time frame: 1 year
All cause Death
Time frame: 1 years
cardiac death
Time frame: 1 years
Myocardial infarction (MI)
Time frame: 1 years
Cerebrovascular accident (CVA)
Time frame: 1 years
Target lesion revascularization (TLR)
Time frame: 1 years
Target vessel revascularization (TVR)
Time frame: 1 years
Any revascularization
Time frame: 1 years
Stent thrombosis: definite or probable stent thrombosis by ARC definition
Time frame: 1 years
BARC bleeding ≥2
Time frame: 1 years
BARC bleeding ≥3
Time frame: 1 years
Major adverse cardiocerebral event (MACCE): death, MI, CVA, or any revascularization
Time frame: 1 years
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