The number of patients with acute congestion on chronic heart failure is increasing. Ultrafiltration has recently been proposed as an alternative approach for the stabilization of volume balance, especially in patients with imminent diuretic resistance. There is increasing evidence that ultrafiltration may relief cardiac congestion with lesser effects on blood pressure and activation of renin angiotensin system, respectively . However, recent studies revealed conflicting results: demonstration the superiority of ultrafiltration in comparison to diuretic treatment, and a lack of evidence of benefit, as well as an excess of adverse events with ultrafiltration. Aquapheresis with adapted ultrafiltration rate guided by central venous pressure is safer than aquaphesis with a constant ultrafiltration with comparable effectiveness
Study Type
OBSERVATIONAL
Enrollment
9
Division of Cardiology, Pulmonary Diseases, Vascular Medicine, University Hospital Dusseldorf
Düsseldorf, Germany
Changes in central venous pressure
Time frame: Changes from Baseline to 48 h after intervention
amount of net fluid loss
Time frame: 48 h
Measure of dyspnea using a visual analog scale
Time frame: Changes from Baseline to 48 h after intervention
heart function
right/left heart function measured by Echocardiography and BNP (Brain Natriuretic Peptide)
Time frame: 7 days
Biomarker
GFR, Cystatin C, HCO3-, NT-proBNP, CK, Troponin, Hematocrit
Time frame: Changes from Baseline to 48 h after intervention
Time until impaired plasma refill rate
Time frame: 48 h
blood pressure
Time frame: Changes from Baseline to 48 h after intervention
heart rate
Time frame: Changes from Baseline to 48 h after intervention
Serum Creatinine level
Time frame: 48 h
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