Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section

Phase 2CompletedNCT02079558

Shahid Beheshti University of Medical Sciences220 enrolled

Overview

Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Enrollment

220

Conditions

Postpartum Hemorrhage

Interventions

CarbetocinDRUG

Carbetocin with single 100 microg IV dosage was used in this investigation

OxytocinDRUG

Oxytocin with 30 international units (IU) IV infusion was used in this investigation

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin Exclusion Criteria: * Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia

Locations (1)

Infertility and Reproductive Health Research Center

Tehran, Tehran Province, Iran

Outcomes

Primary Outcomes

screening of Cessation of bleeding

Time frame: screening until 24 hours after placenta disconnection

time duration to stop bleeding in the case of post-cesarean section

Time frame: 24 hours

Data from ClinicalTrials.gov

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