Observational Study to Assess the Effect of Iluvien® in DME Patients Insufficiently Responsive to Available Therapies

Inclusion Criteria: * Adult patients of both sexes that have signed informed consent after detailed information about the characteristics of the observation by the physician * DME based on physician's clinical evaluation and demonstrated on fundus photographs and/or optical coherence tomography (OCT); * Vision impairment associated with DME * Prior treatment with available therapies for DME; and * Patients considered by the physician insufficiently responsive to available therapies Exclusion Criteria: * Patients with contraindications according to the current Summary of Product Characteristics (SPC) * The presence of pre-existing glaucoma * Active or suspected ocular or periocular infection * The patient is hypersensitive to the active agent or to one of the excipients * Elevated IOP * Pregnancy or breastfeeding