Which Place for High Flow Oxygen in ICU ?

N/ACompletedNCT02080208

Cliniques universitaires Saint-Luc- Université Catholique de Louvain20 enrolled

Overview

Patients with respiratory failure often need oxygen and/or ventilatory support. Patients who need only oxygen support, usually received low flow oxygen (\< 15 Liters / min), as well as in respiratory weaning. Now new devices can be used. They provide high flow oxygen with different benefits. This high flow devices provide exact fraction of inspired oxygen (FiO2), allows a positive end expiratory pressure and supplies a wash out flow. The hypothesis of this study is that the high flow oxygen enable more efficient oxygen administration than conventional oxygen. In addition, it would improve the effectiveness of the ventilation of the patient, through flushing the dead space.

The investigators hypothesized that when using high flow oxygen therapy, respiratory failure is relieved, as well as ventilation failure, so accessories are less stressed muscles, and this can be demonstrated by the electromyography (EMG) of sterno-mastoid..

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Hypoxemia

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: patients with respiratory failure. * Spontaneously breathing patient requiring administration at least 40% oxygen, or, * Patient under mechanical ventilation, during respiratory weaning. Exclusion Criteria: * Facial trauma, active hemoptysis, pneumothorax, thoraco-abdominal surgery or upcoming intubation for spontaneously breathing patients. * Neuromuscular disease, altered consciousness or agitation for patients under mechanical ventilation.

Outcomes

Primary Outcomes

Change from baseline in Oxygenation criteria

Arterial oxygen partial pressure (PO2), oxygen saturation by pulse oximetry (SpO2), arterial PO2/FiO2, positive end expiratory pressure (PEEP)

Time frame: 20 minutes

Secondary Outcomes

Change from baseline in Ventilation criteria

respiratory rate (RR), arterial partial CO2 pressure (PCO2), pH, sterno-mastoid EMG

Time frame: 20 minutes