Radiotherapy is a treatment considered standard for non melanoma skin cancer. This institution uses schemes of 4 to 6 weeks of treatment. The objective of the study is to perform radiation therapy in 1 to 2 weeks, depending on the size of the lesion.
Delineation of radiation field * Gross tumor volume (GTV): disease clinically visible / palpable * clinical target volume (CTV): equal to GTV * planned treatment volume (PTV): * tumors ≤ 2 cm in diameter, with 5-10 mm CTV margin * tumors\> 2-5 cm in diameter, with 15-20 mm CTV margin * Marking the GTV and PTV pen back projection * photograph of the treatment area * protections of the normal structures with blocks of lead, if necessary Technical * Distance focus-skin Tube: 35 cm Locator: 30 and 40 cm * Sizes Tube: 2, 3 and 4 cm in diameter Finder: 6x8 cm, 8x10 cm * Energy: 80 kV 140 kv * Filter 80 kV, 2 mm Al 140 kv, 0.5 mm Copper * Current Draw: 20 mA Dose * tumors ≤ 2 cm in diameter: 5 fractions of 600 cGy, once a day, five times a week - TDF: 89 * tumors \> 2-5 cm in diameter: 10 fractions of 400 cGy, once a day, five times a week - TDF: 96 Clinical revisions every 5 weekly sessions, or a weekly and at the end of treatment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
5 fractions of 600 cGy, once a day, five times a week - TDF: 89
tumors \> 2-5 cm in diameter: 10 fractions of 400 cGy, once a day, five times a week - TDF: 96
Barretos Cancer Hospital - Fundacao Pio XII
Barretos, São Paulo, Brazil
Rate of complete remission with hypofractionated RT schemes for NMSC.
RECIST criteria * Complete Response: disappearance of the lesion * Partial Response: Reduction ≥ 30% of the larger initial diameter of the lesion * Progressive Disease: ≥ 20% increase in the largest initial diameter of the lesion * Stable disease: not increase enough to consider disease progression or reduction sufficient to consider a partial response.
Time frame: Second week and twelfth week after initiation of radiotherapy
Quality of Life
EORTC QLQ-C30
Time frame: Second week and twelfth week after initiation of radiotherapy
Toxicity
Late Effects of Normal Tissue (LENT) SOMA Toxicity Grading and Common Terminology Criteria for Adverse Events (CTCAE) version 3.0.
Time frame: Second week and twelfth week after initiation of radiotherapy
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