PK/PD Study With G-Pump (Glucagon Infusion) in T1DM Patients

Inclusion Criteria: * Males or females diagnosed with type 1 diabetes mellitus for at least 24 months * Current usage of subcutaneous insulin pump treatment * Age 18-65 years * C-peptide level \< 0.5 ng/ml * Willingness to follow all study procedures, including attending all clinic visits * Subject has provided informed consent and has signed and dated an informed consent form before any trial-related activities Exclusion Criteria: * Pregnant and/ or Lactating: For women of childbearing potential: there is a requirement for a negative urine pregnancy test and for agreement to use contraception during the study and for at least 1 month after participating in the study. * HbA1c \>10.0% * Renal insufficiency (serum creatinine of 1.2 mg/dL or greater) * Serum ALT or AST equal to or greater than 3 times the upper limit of normal; hepatic synthetic insufficiency as defined as a serum albumin of less than 3.0 g/dL; or serum bilirubin of over 2.0. * Hematocrit of less than or equal to 34% * Congestive heart failure, NYHA class II, III or IV * History of coronary artery disease * Active foot ulceration * History of a cerebrovascular accident * Active alcohol abuse or substance abuse * Active malignancy, except basal cell or squamous cell skin cancers * Major surgical operation within 30 days prior to screening * Seizure disorder * Current administration of oral or parenteral corticosteroids * Use of an investigational drug within 30 days prior to screening * Bleeding disorder, treatment with warfarin, or platelet count below 50,000 * Proliferative or severe non-proliferative retinopathy * Gastroparesis * Personal or family history of pheochromocytoma or disorder with increased risk of pheochromocytoma (MEN 2, neurofibromatosis, or Von Hippel-Lindau disease) * Insulinoma * Allergies to glucagon or glucagon-like products, or any history of significant hypersensitivity to glucagon or any related products. * Glycogen storage disease * Any concurrent illness, other than diabetes, that is not controlled by a stable therapeutic regimen * Whole blood donation of 1 pint (500 mL) within 8 weeks prior to Screening. * Any reason the principal investigator deems exclusionary