Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation

N/AUnknownNCT02081482

Centre Hospitalier Universitaire de Nice20 enrolled

Overview

The occipital nerve stimulation (ONS) is used to treat patients with refractory primary chronic headache but its mechanism of action (MoA) remains unknown. Different hypothesis have been suggested in particular a specific action on cerebral generators involved in different types of primary headaches or a non specific action on pain modulatory network. The aim of this study, using the chronic cluster headache as a model, is to determine the changes in cerebral metabolism induced by ONS to precise its MoA in the treatment of primary chronic headache.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Refractory Chronic Cluster Headache

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years * chronic cluster headache (according to the IHS) * refractory in who a treatment by ONS have been indicated * patient affiliated at social security, * informed consent signed Exclusion Criteria: * contraindication to MRI * contraindication to 18F-FDG PET * women without contraception/pregnant/breast-feeding * patient non-compliant * patient on legal guardianship

Locations (4)

CHU -Hôpital Gabriel Montpied

Clermont-Ferrand, France

Institut des Neurosciences

Marseille, France

Département d'Evaluation et Traitement de la Douleur - Pôle Neurosciences Cliniques - Centre Hospitalo-Universitaire de Nice

Nice, France

Centre d'Urgence Céphalées

Paris, France

Outcomes

Primary Outcomes

Comparison of cerebral metabolism

Changes of cerebral metabolism associated with ONS efficacy

Time frame: Baseline (before ONS), 1 week after ONS , 3 month after ONS