The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30 years old. By doing this we hope to identify cases of MODY (maturity onset diabetes of the young), which is a rare genetic cause of diabetes that is frequently misdiagnosed. Identifying MODY cases is important, as the treatment may differ to conventional treatment for type 1 or type 2 diabetes.
People who meet the recruitment criteria, will be invited to attend for a single fasted 2 hour visit at our research facility. During the visit we will record details of their diabetes history as well as their general health and undertake blood and urine tests. At the end of the visit their participation will be complete. We will contact them later to discuss results of specialist blood tests and whether or not they have MODY, if they have had genetic testing performed.
Study Type
OBSERVATIONAL
Enrollment
916
Imperial College Clinical Research Facility
London, United Kingdom
RECRUITINGFrequency of MODY
Comparison of frequency of MODY mutations between two ethnic groups
Time frame: 5 years
Comparison of biochemical and clinical characteristics in people with MODY between each ethnic group.
* Difference in fasting C-peptide levels between UK South Asian and white European people * Difference in BMI, waist and hip circumference between UK South Asian and white European people * Differences in affected gene between UK South Asian and white European people
Time frame: 5 years
Comparison of clinical and biochemical characteristics of other subtypes of diabetes
In people phenotyped as type 1 or type 2 diabetes: * Difference in fasting C-peptide levels between UK South Asian and white European people * Difference in BMI, waist and hip circumference between UK South Asian and white European people * Differences in diabetes antibody positivity between UK South Asian and white European people
Time frame: 5 years
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