It has been shown that N-methyl-D-aspartate (NMDA) receptor antagonists (such as ketamine) potentiate analgesic drug's efficacy. Polyamines are allosteric modulators of NMDA receptors. In animal studies, polyamine-free diet has shown antinociceptive properties. This research aims at evaluating analgesic properties of polyamine-low diet after laparoscopic cholecystectomy performed in an ambulatory setting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
38
Hôpital de la Croix Saint-Simon
Paris, Hauts de Seine, France
Pain intensity for the 7 days
Pain intensity is evaluated by the number of tablets of Tramadol taken by the patients
Time frame: 7 days
Pain scores measured on the day of surgery,
Pain score (numerical scale from 0 to 10) measured in mid-afternoon, resting lying down, coughing and mobilization (from lying to sitting position)
Time frame: 12 hours
frequency of impeded hospital discharge the day of surgery
Failure of outpatient care (i.e. the patient cannot leave the hospital the day of surgery)
Time frame: 24 hours
Each day pain
Pain scores (numerical scale from 0 to 10) assessed daily from J1 ( after surgery) to J7 in mid afternoon , lying at rest position , coughing and mobilization (from lying to sitting position) .
Time frame: 7 days
Quality of life
QLQC30 Questionnaire (version 3)
Time frame: 7 days
Residual pain
Pain score (numerical scale from 0 to 10)
Time frame: 30 days
Blood levels of polyamine
Blood samples are performed the day of surgery and at J7. The dosages will be performed when all patients will be recruited
Time frame: 2 years
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