The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive agent compared with nitroglycerin.
The subject included the healthy patients who underwent orthognathic surgery and gave written the informed consent. The sample size was calculate from the amount of fentanyl use in orthognathic surgical case and difference more 30% was significant. Randomization was done by random number table to 2 groups. Both groups received standardized controlled hypotensive anesthesia and surgery. D group used dexmedetomidine as the hypotensive drug and N group use nitroglycerin. The main outcome were the amount of fentanyl use, time to eye opening, follow simple command, extubation, early postoperative pain, and early postoperative amount of pain killer. All recorded by anesthesiologist on data sheet. compare statistical analysis used compare mean by unpaired student t test.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
controlled hypotensive anesthesia with dexmedetomidine compare with nitroglycerin on anesthetic outcome such as analgesic use, time to eye opening, follow verbal command, extubation and early postoperative pain
controlled hypotensive anesthesia with nitroglycerin compared with dexmedetomidine on anesthetic outcomes such as analgesic use, time to eye opening, follow verbal command, extubation, and early postoperative pain.
Faculty of dentistry, Mahidol university
Rajthevi, Bangkok, Thailand
amount of intraoperative fentanyl
Record the amount of fentanyl used in the operation.
Time frame: intraoperatve period
time to eye opening
the time that counted from closed anesthetic drugs and reversed muscle relaxant to patients eye opening.
Time frame: emergence of anesthesia
time to follow verbal command
the time that counted from closed anesthetic drugs and reversed muscle relaxant to patients can follow simple verbal command such as open mouth, protrude the tongue, move the hand.
Time frame: emergence of anesthesia
time to extubation
the time that counted from closed anesthetic drugs and reversed muscle relaxant to remove the nasotracheal tube.
Time frame: emergence of anesthesia
postoperative pain score at 30 minute
postoperative pain score at 30 minute using 10-point pain assessment scale.
Time frame: early postoperative period
postoperative pain score at 60 minute
postoperative pain score at 60 minute using 10-point pain assessment scale.
Time frame: early postoperative period
amount of pethidine
Record the amount of pethidine that used for a pain killer when pain score more than 4 in first 2 hours post-operation.
Time frame: early postoperative period (first 2 hours)
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