The aim of the work is to evaluate \& compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood loss during and after the operation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
636
Comparison of different routes of administration of 400 micro gram misoprostol
Ain Shams University Maternity Hospital
Cairo, Egypt
Intraoperative Blood Loss
Time frame: from start of cesarean section till the end of operation (average one hour)
Need for Extra Ecbolics (Oxytocin).
Time frame: from start of cesarean section till the end of operation (average one hour)
APGAR Score
The Apgar score is the first test given to a newborn, it is referred to as an acronym for: Appearance, Pulse, Grimace, Activity, and Respiration. Scores obtainable are between 10 and 0, with 10 being the highest possible score. Pulse: above 100 beats per minute (2), below 100 beats per minute (1), absent (0). Respiration: Normal rate and effort, good cry (2), Slow or irregular,weak cry (1), absent (0). Grimace: Pulls away, sneezes, coughs, or cries with stimulation (2), Facial movement only (1), absent (0). Activity: Active, spontaneous movement (2), Arms and legs flexed with little movement (1), absent (0). Appearance: Normal color (2), Normal color (but hands and feet are bluish) (1), Bluish-gray or pale all over (0).
Time frame: 1minute and 5 minutes from delivery of the fetus
Time to Resume Bowel Habits
Time frame: average 24 hours
Need for Extra Analgesics
Time frame: average 24 hours
Need for Postoperative Blood Transfusion
Time frame: average 24 hours
Incidence of Wound Sepsis
Time frame: upto one week
Incidence of Adverse Effects
Time frame: 24 hours
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