C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

N/AUnknownNCT02083159

Korea University500 enrolled

Overview

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

NAFLD

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 20\<age\<80 * apparently healthy subjects Exclusion Criteria: * a history of CVD * diabetes * stage 2 hypertension * malignancy * severe renal or hepatic disease

Locations (1)

Korea Univ. Guro Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD

Time frame: at enrollment

Secondary Outcomes

The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles