Non Invasive Ventilation as Airway Clearance in Patients With Cystic Fibrosis

N/ACompletedNCT02083263

Karolinska University Hospital32 enrolled

Overview

With the use of Non invasive ventilation the patients with cystic fibrosis will have better lung function (FEV1).

3 months intervention between PEP an Bilevel. The patients will follow up under 3 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cystic Fibrosis

Interventions

BilevelDEVICE

3 months

PEP maskDEVICE

3 months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with CF older than 18 years * FEV1 between 20% and 69% of predictive. * No acute exacerbation. * No Burkhordelia Cepacia/MRSA colonization. Exclusion Criteria: * Children under 18 year * acute exacerbation.

Locations (1)

Cecilia Rodriguez

Stockholm, Stockholm County, Sweden

Outcomes

Primary Outcomes

Lung Function: Lung Clearance Index

Lung clearance index was calculated as the number of lung volume turnovers (cumulative expired volume divided by the functional residual capacity) required to reduce end-tidal nitrogen concentration to 1/40th of the starting value.

Time frame: up to 3 months

Secondary Outcomes

Blood Gases:1 Month After Chest Physiotherapy Will Take Blood Gases (Kpa).

After physiotherapy will take blood gases (kpa) before chest physiotherapy and perform once a month.

Time frame: 1 month

Data from ClinicalTrials.gov

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