Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects

Inclusion Criteria: * Informed consent * Healthy adult males age 18 - 50 years, BMI 19-32 kg/m2 * Acceptable duration of cold pain test results at screening Exclusion Criteria: * Clinically significant medical illness or physical exam findings * Active dermatological conditions or skin trauma on the non-dominant hand, or peripheral vascular disease * Partial blindness, keratoconus, nystagmus or any other ophthalmic condition which could interfere with pupillometry * Use of tobacco or nicotine within 6 months prior to screening * History of recent (within 6 months) drug or alcohol abuse, as defined in DSM-IV-TR