Apolipoprotein CIII Reduction Via Colchicine

Inclusion Criteria: * Acute new-onset pericarditis or recurrent pericarditis (≥2 following criteria) * Sharp and pleuritic chest pain improved or relieved by sitting up and leaning forward * A pericardial friction rub * Electrocardiogram (EKG) findings of diffuse ST-segment elevations or PR depression * New or worsening pericardial effusion visualized on echocardiogram. OR •Acute gouty arthritis (according to the ACR; ≥1 of following criteria: * Joint fluid containing urate crystals * Tophus proved to contain urate crystals by chemical means * Polarized light microscopy * Presence of six of the following in the absence of crystal identification: * \>1 attack of acute arthritis * Maximum inflammation developed in 1 day * Monoarthritis attack * Redness observed over joints * 1st metatarsal joint painful or swollen * Unilateral 1st metatarsal joint attack * Unilateral tarsal joint attack * Tophus (suspected) * Hyperuricemia * Asymmetric swelling within a joint visible on physical examination or radiography * Subcortical cysts without erosions visible on radiography * Monosodium urate monohydrate microcrystals in joint fluid during attack * Joint fluid culture negative for organisms during attack. If N \< 10 after 3 weeks of trial initiation, then employ enrollment strategy #2 Enrollment strategy #2: * History of hypertriglyceridemia (TG ≥ 150 mg/dL) AND * Age ≥ 18 years old * Capable of providing informed consent * Capable of taking Colchicine 0.6-1.2 mg/day orally for 6 weeks * Capable of providing a blood sample Exclusion Criteria: * Colchicine use \< 8 weeks from baseline VAP panel * Pregnant or female of child bearing age * On corticosteroid therapy or corticosteroid use \< 4 weeks from baseline VAP panel * History of statin myopathy or hepatotoxicity * History of colchicine intolerance or hypersensitivity * Severe end-stage renal disease (eGFR ≤ 20 mL/min/1.73 m2) or requiring dialysis * Hepatic Impairment (Child-Pugh class B or C) * Myopericarditis (If TnI is elevated on presentation of acute pericarditis) * Inflammatory Bowel Disease * Tuberculous, neoplastic, or purulent pericarditis