Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation

N/ACompletedNCT02083809

University of Hawaii166 enrolled

Overview

Currently, there is very little research to identify ways to decrease blood loss during D\&E (dilation and evacuation) procedures. The objective is to determine whether routine use of intravenous oxytocin will improve bleeding outcomes at the time of D\&E at 18-24-weeks gestation. To evaluate the hypothesis, investigators will perform a randomized, double-blinded, placebo-controlled trial. The patient will be followed until discharged from the postoperative care unit during which time patient satisfaction, pain score and postoperative bleeding will be assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

166

Conditions

Abortion Dilation and Evacuation Hemorrhage Blood Loss

Interventions

Eligibility

Sex: FEMALEMin age: 14 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Requesting pregnancy termination * Intrauterine pregnancy at 18- to 24-weeks gestation * Gestational-age to be confirmed by ultrasound * Patients with fetal anomaly or intrauterine fetal demise that occurred at 18- to 24-weeks gestation * Willing and able to understand and sign written informed consents in English or Spanish and comply with study procedures Exclusion Criteria: * Ultrasound findings suggestive of placenta accreta * Patients requiring preoperative misoprostol

Locations (2)

University of Hawaii

Honolulu, Hawaii, United States

University of Washington

Seattle, Washington, United States