The medium cut-off dialysis membrane has been developed to provide a significantly extended molecular cut-off compared to conventional high-flux membranes. The medium cut-off membrane allows for a high permeability of molecules up to a molecular weight of 45 kDa and has a still limited permeability for albumin (68 kDa). The main goal of this project is the evaluation of the new, highly porous and selective dialysis membrane (MCO-Ci 400) for the treatment of patients with end-stage renal disease in hemodialysis mode and to study its potential to improve chronic inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
hemodialysis
hemodialysis
Martin-Luther-Universität Halle-Wittenberg
Halle, Saxony-Anhalt, Germany
Charité - Universitätsmedizin Berlin
Berlin, Germany
TNF-alpha mRNA
Significant lower pre- dialytic TNF-α mRNA expression level in circulating peripheral blood mononuclear cells
Time frame: 4 weeks treatment time
safety related events
Time frame: 6 month
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