A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD)

Inclusion Criteria: * Body mass index of 18-40 kg/m2 * Have a diagnosis of MDD * Have a current major depressive episode (MDE) lasting 8 weeks to 24 months * Have been treated with an adequate dose of an approved antidepressant during the current MDE for at least 8 weeks * Have an inadequate response to current antidepressant treatment * Agree to use an approved method of birth control for the duration of the study * Additional criteria may apply Exclusion Criteria: * Currently pregnant or breastfeeding * History of or current infection with Hepatitis B Virus, Hepatitis C Virus or Human Immunodeficiency Virus (HIV) * Have experienced hallucinations, delusions, or any psychotic symptoms in the current MDE * Have used opioid agonists (eg, codeine, oxycodone, tramadol, or morphine) or opioid antagonists (eg, naloxone, naltrexone) within 14 days * Have received electroconvulsive therapy treatment within the last 5 years * Have attempted suicide within the past 2 years * Have a history of intolerance, allergy, or hypersensitivity to buprenorphine or opioid antagonists (eg, naltrexone, naloxone) * Have had a significant blood loss or blood donation with 60 days of screening * Additional criteria may apply