Hyperbaric Oxygen Therapy for Mild Cognitive Impairment

Inclusion Criteria: * Patients diagnosed as suffering from Mild Cognitive Impairment by-National Institute on Aging Alzheimer Association criteria. * Patients diagnosed as suffering from MCI to be due to Vascular Subcortical Ischemia by subcortical vascular changes in MRI, according to the MRI protocol of the European multicenter leukoaraiosis and disability study protocol. * At least 1 of the following vascular risk factors arterial hypertension or known hypertension treated by blood pressure lowering medications, hypercholesterolemia. * The onset of the disease is slow and gradual * The course is continuously or step-like progressive for more than 1 year * Patients who are ambulatory * No other active neurological, systemic or psychiatric conditions that might be the primary cause of the current syndrome or significantly affect the current cognitive disorder. * No previous brain disorder except the current contingency of the cognitive disorder. * Balanced systemic psychiatric state for the past 3 months. Exclusion Criteria: * Dynamic neurologic improvement or worsening during the last month * Had been treated with HBOT for any other reason prior to their inclusion * Have any other indication for HBOT * Chest pathology incompatible with pressure changes * Inner ear disease * Patients suffering from claustrophobia * Patients suffering from any active malignant disease * Inability to sign written informed consent. * Patients with cognitive changes which cannot be defined as Mild Cognitive Impairment by National Institute on Aging Alzheimer Association criteria and global CDR score. * Patients who do not have Vascular Subcortical Ischemia by the subcortical vascular changes in MRI according to the European multicenter leukoaraiosis and disability study protocol. * The onset of the disease is not slow and gradual. * The course is not continuously or step like progressive for more than 1 year. * Patients who are not ambulatory * There are other active neurological, systemic or psychiatric conditions that might be the primary cause of the current syndrome or significantly affect the current cognitive disorder. * Any previous brain disorder except the current contingency of the cognitive disorder. * Patients whose systemic psychiatric state is not balanced for the past 3 months.