Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (\~ 2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.
Study Type
OBSERVATIONAL
Enrollment
100
Uppsala University Hospital
Uppsala, Sweden
RECRUITINGChanges in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery)
Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery
Time frame: 1 year
The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention)
No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery
Time frame: Measures 1 y, 2 y, and 5 y after surgery.
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