Lactobacillus Brevis CD2 Preventing Oral Mucositis

Inclusion Criteria: * Age between 18 and 65 years * Karnofsky Performance Score ≥ 70%. * Confirmed histological diagnosis of multiple myeloma for which HSCT is as approved modality of therapy * Patients eligible to receive high-dose chemotherapy as part of conditioning regimen * Concomitant co morbid condition if present, controlled by ongoing treatments (e.g. hypertension, diabetes and so on) * Serum creatinine \< 1.8mg/dl * Total bilirubin \< 2mg/dl * Liver enzymes within three times of normal limit * Expected survival \> 6 months. Exclusion Criteria: * Pregnant women and lactating mothers * Patients with history of HIV infection * Patients who have taken any other investigational product in last 4 weeks * Patients having untreated symptomatic dental infection * Patients with WHO Grade 3 or 4 oral Mucositis * Other serious concurrent illness * Inconclusive hematological diagnosis * Patients with signs and symptoms of systemic infections * Patient's/guardian's refusal to sign informed consent