Gait and posture disorders are very common in subjects aged 65 and over, and result mainly from neuromuscular and cognitive disorders. Many studies have shown that 1) vitamin D deficiency is very common in women aged 65 and over, 2) individuals with hypovitaminosis D have lower muscle, gait and executive performances and are more prone to fail than individuals with no hypovitaminosis D, 3) the intake of vitamin D combined or not with calcium may improve muscle strength and cognitive performance. The investigators hypothesized that the daily intake of 2 yogurts containing 200 IU of vitamin D and 400 mg of calcium 1) can improve spatiotemporal gait parameters, posture and executive performance, 2) and that this improvement depends of the initial level of vitamin D deficiency.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
40
The product is a yogurt containing 200 IU of vitamin D and 400 mg of calcium. Participants take 2 yogurts per day.
The comparator is represented by a yogurt not supplemented with vitamin D and calcium.Participants take 2 yogurts per day.
Centre Hospitalier Universitaire d'Angers
Angers, Maine et Loire, France
Change in spatiotemporal gait, and in particular in the variability of stride time
Stride time variability is measured with spatiotemporal analysis of walking
Time frame: This outcome is assessed at baseline and 12 weeks after oral intake.
Change in posture
Posture is evaluated with Time Up \& Go, Five Time Sit-to-Stand and posture analysis with a platform.
Time frame: This outcome is assessed at baseline and 12 weeks after oral intake.
Change in grip strength
Grip strength is measured with a dynamometer.
Time frame: This outcome is assessed at baseline and 12 weeks after oral intake.
Change in executive performance
Executive performance is measured with Trial Making Test part B (TMT B)
Time frame: This outcome is assessed at baseline and 12 weeks after oral intake.
Change in other cognitive scores
Executive scores are assessed with digit span test (forward and backward), Trial Making Test part A (TMT A), Stoop test and Processing Speed Index
Time frame: These outcomes are assessed at baseline and 12 weeks after oral intake.
Change in the serum concentration of 25 OHD
This outcome is assessed with the serum concentrations of 25OHD
Time frame: This outcome is assessed at baseline and 12 weeks after oral intake.
Compliance to intervention
Compliance is measured by the number of yogurt capsules returned
Time frame: This outcome is assessed 12 weeks after oral intake.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.