Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers

Inclusion Criteria: * women with proven pathogenic BRCA1/2 mutation Exclusion Criteria: * metastatic tumor disease * life expectancy \<3 years * clinically limiting cardiovascular or respiratory disease * significant orthopedic disability which prevents from participating in the exercise training * severe concomitant disease which prevents from participating in the group interventions * Karnofsky index \<60 * VO2max \>150% * Maximal exercise capacity \< 50 W * food allergies which prevent from mediterranean diet * vegan diet * body mass index \<15 kg/m2 * pregnancy * insufficient knowledge of German language * insufficient compliance * active participation in other interventional trials * no informed consent