Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis

Inclusion Criteria: * Patients with ability and willing to provide written informed consent and comply with the requirements of the study protocol. * Patients with active moderate or severe rheumatoid arthritis, according to 1987 ACR criteria, diagnosed at least 6 months before inclusion. * 18 years old or older * DAS28 index greater than 3.2 at baseline. * If patients are receiving corticosteroid the dose will have to be ≤ 10 mg of prednisone (or equivalent) and the patient must have been stable for at least one month previous to initiating treatment with Tocilizumab (day 1). Patients may have been treated with nonsteroidal antiinflammatory drug (NSAIDs) at stable doses during the previous month to inclusion. * Patients receiving outpatient treatment. * Women of childbearing potential and men with childbearing potential partners may only participate in the study if they use reliable contraception (eg barrier methods \[the patient or her partner\], oral or patch contraceptives, spermicide and barrier method or intrauterine device) during the study period and at least 3 months after receiving the last dose of Tocilizumab. * In women of childbearing potential the pregnancy test must be negative at the screening visit and at baseline. * Patients on methotrexate monotherapy or combined treatment with a biological agent, or patients on biological treatment monotherapy, who show or have ever shown intolerance or poor compliance or safety issues with methotrexate. * Patients judge to be candidates to biological monotherapy by the researcher, without excluding previous use of other disease-modifying antirheumatic drug (DMARDs) different to methotrexate. Exclusion Criteria: * Patients with no peripheral venous access. * Patients with previous failure to more than two biological treatments. * Previous treatment with Tocilizumab at any time before the baseline visit. * Treatment with any other agent on research during the four weeks previous to the screening visit (or equivalent period to its five half-lives) Considering the longest period. * Previous treatment with cell depletion therapies, including experimental treatments or approved agents, as for examples: CAMPATH, antiCD4, antiCD5, antiCD3, antiCD19 and antiCD20). * Treatment with intravenous gammaglobulin or plasmapheresis in the 6 months previous to the baseline visit. * Intra-articular or parenteral corticosteroids within 4 weeks previous to the baseline visit. * Immunization with a live / attenuated vaccine in the previous 4 weeks to the baseline visit. * Previous treatment with alkylating agents such as chlorambucil, or full lymphoid irradiation. * History of severe allergic or anaphylactic reactions to human, humanized or murine, monoclonal antibodies. * Evidence of serious uncontrolled concomitant disease: cardiovascular, nervous system, lung (including chronic obstructive pulmonary disease), renal, hepatic, endocrine (including uncontrolled diabetes mellitus) or gastrointestinal. * History of diverticulitis, diverticulosis requiring treatment with antibiotics, or chronic lower gastrointestinal ulcer disease, Crohn's disease, ulcerative colitis or any other lower gastrointestinal symptomatic conditions that could predispose to perforations. * Known active Infections, or a history of known recurring infections: Mycobacterial, fungal, viral or bacterial type (included, but not limited to, tuberculosis, atypical mycobacterial disease, hepatitis B and C, herpes zoster, but excluding nail bed fungal infections). * Any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 4 weeks previous to the screening visit or oral antibiotics within 2 weeks previous to the screening visit. * Active tuberculosis requiring treatment in the past year. Latent tuberculosis screening will be perform on all patients according to Spanish Society of Rheumatology/Spanish Agency for Medicines and Health Products (SER/AEMPS) guidelines of the. Patients treated for tuberculosis without recurrence in the past 3 years will not be excluded. * Ongoing liver disease as determined by the principal investigator. * Evidence of active malignancy, malignancies diagnosed in the previous 10 years (including solid and hematologic tumors, except basal cell carcinoma and squamous cell skin or removed and cured in situ cervix carcinoma), or breast cancer diagnosed in the previous 20 years. * Pregnant or breastfeeding women. * Patients with reproductive potential who are unwilling to use effective contraception. * History of alcoholism, drug abuse or addiction in the previous year to the screening visit. * Neuropathies or other painful conditions that may interfere with pain assessment. * Serum creatinine \>1,4 mg/dl (124 mol/l) in women and \>1.6 mg/dl (141 mol/l) in men. * Alanine aminotransferase or aspartate aminotransferase \> 1.5 times the upper limit of normal. * Total bilirubin greater than the upper limit of normal. * Platelet count minor than 100 x 10\^9/l (100.000/mm3). * Hemoglobin minor than 85 g/L (\<8,5 g/dL, 5,3 mmol/L). * Leukocytes minor than 3,0 x 10\^9/L (3000/mm3). * Neutrophils, absolute value minor than 2,0 x 10\^9/L (2000/mm3). * Lymphocytes, absolute value minor than 0,5 x 10\^9 /L (500/mm3).