Measurement of Urinary Catabolites of PACs as Biomarkers of Consumption of Cranberry Extracts

Phase 1CompletedNCT02087735

Laval University15 enrolled

Overview

The purpose of this cross over pilot study is to investigate the urinary catabolites of Proanthocyanidines (PACs) as biomarkers of cranberry extracts in healthy young women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Urinary Tract Infections

Interventions

Cranberry extractDIETARY_SUPPLEMENT

The aim of this pilot study is to evaluate the urinary catabolites of PACs as a biomarker of consumption of cranberry extracts within 9 hours of intercourse. Once a week, for 3 weeks, the women will receive a sequence of 3 different cranberry extracts (72 mg, 36 mg and 2mg (placebo)). The participant will have to collect its urine for a period of 9 hours in 3 different containers (one different container for 3 hours).

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy women. * 18 to 40 years. Exclusion Criteria: * No internet access. * No refrigerator access during the 9 hours of sample collection. * Women who had or expect to take antibiotic. * Women who had or expect to take cranberries, blueberries or bilberries in the form of berries, juice or extracts. * Women who had or expect to take dark chocolate. * Women who had personal history of acute or chronic renal failure.

Locations (1)

Laval University, Department of Medecine, Institut sur la nutrition et les aliments fonctionnels (INAF).

Québec, Quebec, Canada

Outcomes

Primary Outcomes

Urinary catabolites of PACs

Time frame: within 9 hours following the intake of cranberry extracts

Data from ClinicalTrials.gov

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