Kidney Cancer DNA Registry

N/ARecruitingNCT02087852

Memorial Sloan Kettering Cancer Center750 enrolled

Overview

This registry will help us develop better methods of: * Preventing these cancers * Diagnosing these cancers * Treating these cancers

Study Type

OBSERVATIONAL

Enrollment

750

Conditions

Renal Cancer

Interventions

salvia for germline DNAOTHER

the Kidney Cancer QuestionnaireBEHAVIORAL

Patients will complete the appropriate surveys on either paper or on the computer/iPad in the office using REDCap software. If patients are unable to complete their questionnaires at the time of their in-office visit, a link to the questionnaires in REDCap will be emailed to them. The survey data that is collected in REDCap will be stored in REDCap. Clinic staff may also call patients to remind patients to complete questionnaires.

Family History Questionnaire (when applicable)BEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Kidney Cancer Case Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must have a diagnosis or suspicion of kidney cancer Family Member Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required. Control Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND * Must not be a blood relative of any cases or controls enrolled in this study Exclusion Criteria: * Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent

Locations (7)

Memorial Sloan Kettering at Basking Ridge (Consent and Follow-up)

Basking Ridge, New Jersey, United States

RECRUITING

Memorial Sloan Kettering Monmouth (Consent and Follow up)

Middletown, New Jersey, United States

RECRUITING

Outcomes

Primary Outcomes

establish a kidney cancer registry

with detailed epidemiologic data and germline DNA available for next generation sequencing from consenting patients, selected family members, and healthy unrelated controls.

Time frame: 5 years

Central Contacts

Jonathan Coleman, MD

CONTACT

646-422-4432

Kenneth Offit, MD

CONTACT

646-888-4050

Data from ClinicalTrials.gov

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