Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development. An altered composition of intestinal microflora results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. These findings support the concept that specific beneficial bacteria from human intestinal microflora, designated probiotics, could restore intestinal microflora homeostasis and prevent or treat FA.
Study Type
OBSERVATIONAL
Enrollment
600
University of Naples Federico II
Naples, Italy
RECRUITINGComposition and function gut microbiota in children with cow milk allergy and healthy children
Time frame: Change from baseline at 6 and 12 months
Composition and function gut microbiota comparing cow milk allergy Italian and cow milk allergy children of other countries
Time frame: Change from baseline at 6 and 12 months
Composition and function gut microbiota comparing healthy Italian and healthy children of other countries
Time frame: Change from baseline at 6 and 12 months
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