The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus. So the corneal cross linking in association with the antibiotic treatment could result in a reduction of the duration of epithelial complete healing of the cornea.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
21
The procedure of the cross linking is standard:combined riboflavin(Ricrolin®)-ultraviolet type A rays (UVA) collagen cross-linking. Radiant energy was 3 milliwatts/cm2 or 5.4 joule/cm2 for a 30-minute exposure irradiation of the cornea. Patients are checked every days during the hospitalisation and one week, one month and 3 months after the hospitalisation.
If not the contact lens wearer -\> Cocci Gram positive cocci * Vancomycin + Fortum If contact lens wearer -\> Gram negative bacillus * Fortum + Amiklin If corticosteroids, immunosuppression, latent evolution -\> Fungus. = Fortum + vancomycin + Fungizone
Orignac
Nantes, France
Duration of corneal complete epithelial healing in days.
Time frame: 3 months
Size of the corneal scar
Size of the corneal scar at 3months expressed in % of the initial size of the corneal ulcer.
Time frame: 3months
Corneal thinning
Corneal thinning estimated by Anterior segment optical coherence tomography at 3 months, expressed in microns.
Time frame: 3 months
Gain of visual acuity
Gain of visual acuity, corresponding to the difference between the initial visual acuity and the 3months one. The visual acuity is measured with monoyer scale and converted in log Mar.
Time frame: 3 months
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