The aim of this study is to see whether antibiotics given at the start of laparoscopic kidney donation surgery prevent infection.
Subjects undergoing laparoscopic donor nephrectomy will be randomised to either a single dose of intravenous co-amoxiclav or placebo prior to surgery. Outcome measures include any infections, length of stay and costs
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
284
Will receive 1.2g co-amoxiclav at induction
Placebo - 0.9% saline
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
Rate of infection after surgery
Time frame: 24 months
Ultrasonic evidence of wound healing
Wounds will be assessed using high resolution ultrasound to assess dermal and epidermal healing.
Time frame: 24 months
Length of hospital stay
Time frame: 24 months
Readmission rates
Time frame: 24 months
Antibiotic associated side effects
Including diarrhoea and allergic reactions
Time frame: 24 months
Return to work and normal activities
Time frame: 24 months
Quality of life
Time frame: 24 months
Relative costs
Time frame: 24 months
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