Decreased cerebral oxygen saturation (rSO2) was reported to occur during insufflation for laparoscopic procedures due to increased Intracranial pressure (ICP) with resultant decrease in cerebral perfusion pressure.
Forty patients scheduled for laparoscopic cholecystectomy will be enrolled in this double blind, randomized controlled study. Patients will receive either 0.5g/kg of 20% intravenous (i.v.) mannitol infusion over 10 minutes immediately before induction of anesthesia (group M) or an equal volume of 0.9% normal saline instead (group C). Primary outcome measure is rSO2. Secondary outcome variables include extubation time, clinical assessment of consciousness recovery using the modified Observer's assessment of alertness/sedation scale (OAA/S) and the mini-mental state examination (MMSE) for cognitive evaluation after recovery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Anesthesia Department, University of Dammam
Khobar, EP, Saudi Arabia
King Fahd Hosital of the University
Khobar, EP, Saudi Arabia
rSO2
Time frame: participants will be followed for the duration of surgery, an expected average of 1 hour
extubation time
time from end of anesthesia to fulfilling extubation criteria
Time frame: intraoperative
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.