Efficacy of Motilitone on Gastric Accommodation in Healthy Adult Patients: Evaluation Using MRI Method

Inclusion Criteria: * Healthy volunteers between 20 and 70 years of age without upper abdominal pain or discomfort and a structural abnormality on upper gastrointestinal (GI) endoscopy performed within the preceding 6 months were eligible for the trial. Exclusion Criteria: * Patients were excluded if they met any of the following criteria: 1. any functional GI disease or previous abdominal surgery 2. diabetes mellitus under insulin or oral anti-hyperglycemic agent treatment 3. significant cardiopulmonary diseases or any malignancies 4. significant renal (serum creatinine level ≥ 1.5 × the upper normal limit) or liver disease (serum aspartate aminotransferase and alanine aminotransferase levels ≥ 2.5 × the upper normal limits 5. taking medications that may alter gastric function within 2 weeks prior to the start of the study 6. pregnancy or lactation 7. females with inadequate contraception during the study period 8. contraindications to MRI (e.g., cardiac pacemaker or metallic aneurysm clip) 9. allergic history to motilitone 10. other conditions likely to interfere with study procedures, as judged by the investigator