Evaluation of Neuroinflammation in Children With Infantile Spasms

Phase 4CompletedNCT02092883

Wayne State University8 enrolled

Overview

The purpose of this study was to investigate the presence of neuroinflammation in children with infantile spasms using 11C-PK11195 positron emission tomography (PK PET) scan, and its response to ACTH treatment by repeating the PK PET scan after treatment.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Infantile Spasms

Interventions

ACTHDRUG

PK PET scan before and after ACTH treatment

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * A clinical diagnosis of 'cryptogenic IS' * Normal MRI * No other neurological disorder Exclusion Criteria: * Abnormal MRI * No anti-inflammatory medication 48 hrs prior to PK PET scans * Parent/guardian unable to give written consent

Locations (1)

Children's Hospital of Michigan

Detroit, Michigan, United States

Outcomes

Primary Outcomes

Neuroinflammation in cortical and/or subcortical structures

Neuroinflammation in cortical and/or subcortical structures of the brain in patients with Infantile Spasms will be evaluated with 11-C-PK11195 PET scan at the baseline and 2 weeks after the completion of ACTH treatment (given over 4 weeks), i.e., 6 weeks after the baseline PET scan.

Time frame: up to 6 weeks

Data from ClinicalTrials.gov

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