Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study

N/ACompletedNCT02093416

University of Pittsburgh50 enrolled

Overview

Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants. The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Endoscopic Intervention Exclusion Criteria: * 18 years of age or older * No acute GI bleeding

Locations (1)

University of Pittsburgh/UPMC Presby

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

PCR test for Leptin Receptors

Endoscopic biopsies of enterocytes will be measured via PCR

Time frame: 1 week

Secondary Outcomes

ELISA test for ghrelin, motilin, leptin and PYY

Blood samples collected to determine hormones via ELISA

Time frame: 1 week

IWQOL lite questionnaire

Quality of Life questionnaire on obesity

Time frame: 1 week

Data from ClinicalTrials.gov

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