Assessing the Severity of Metabolic-related Liver Injuries in Aging HIV-monoinfected Patients

Inclusion Criteria: 1. Age ≥40 years 2. Infection with HIV-1 3. Cumulative exposure to cART for at least 5 years and currently under cART 4. Viral load \< 400 copies/mL 5. CD4 count \> 100 CD4/mm3 6. Female may be eligible to enter and participate in the study if she: * is of non-child-bearing potential defined as either post-menopausal (12 months of spontaneous amenorrhea and ≥45 years of age) or physically incapable of becoming pregnant with documented tubal ligation, hysterectomy or bilateral oophorectomy or * is of child-bearing potential with a negative blood pregnancy test at screening visit 7. Informed consent signed prior to any study procedure 8. To be covered by a medical insurance (only for French centres) 9. Presence of: * the metabolic syndrome as defined by the most recent international consensus definition (Alberti et al. Circulation 2009) including three components among the following criteria: * visceral obesity (waist circumference: Europeans and Africans ≥ 94 cm for men and ≥ 80 cm for women, Americans ≥ 102 cm for men and ≥ 88 cm for women, Asians ≥ 90 cm for men and ≥ 80 cm for women) * blood glucose ≥ 1 g/L (5,6 mmol/L) or anti-diabetic treatment, * serum triglycerides ≥ 1,5 g/L (1,7 mmol/L) or hypertriglycerides treatment, * serum HDL cholesterol \< 0,4 g/L (1 mmol/L) for men and \< 0,5 g/L (1,3 mmol/L) for women or hypercholesterolemia treatment, * blood pressure (Diastolic ≥130 mmHg and/or Systolic ≥ 85 mmHg) or antihypertensive treatment * and/or clinical lipoatrophy and/or lipohypertrophy using clinical questionnaires used and validated in previous published studies (ANRS 121 Hippocampe trial), * and/or chronic elevated transaminases ≥ 1.5 ULN and / or GGT ≥ 2 ULN confirmed by two blood samples within at least three-month interval over twelve months prior screening visit. Exclusion Criteria: 1. Coinfection with hepatitis B (positive HBs antigen or isolated positive HBc antibody with positive PCR) 2. Positive HCV serology 3. Coinfection HIV-1 and HIV-2 4. Use of intravenous drugs within the last six months 5. Excessive alcohol intake (male \> 50 g/d, female \> 40 g/d) 6. Other causes of liver diseases i.e: viral hepatitis, hemochromatosis, Wilson disease, autoimmune hepatitis, primary or secondary biliary cirrhosis, primary or secondary cholangitis, α1 antitrypsine deficiency 7. Other causes of liver steatosis: current steroid therapy, current therapy with amiodarone, tamoxifen, methotrexate, nifedipine, or hycanthone; history of cancer chemotherapy; short bowel syndrome, polycystic ovarian syndrome, Weber-Christian disease 8. Active opportunistic infection except for candida oesophagitis 9. Current Cancer 10. Pregnancy 11. Decompensated heart failure 12. Subject under legal guardianship 13. Inability to give informed consent or incapacitation 14. Contra-indication to MRI: pace-maker, neurovascular surgery, intraocular materials, cochlear implant, severe claustrophobia 15. Participation in another study with an ongoing exclusion period at screening