The Interaction Between Appetite Hormones

N/ACompletedNCT02094183

University of Copenhagen58 enrolled

Overview

Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change

Many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of GLP-1.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Obesity

Interventions

GLP-1OTHER

GLP-1

low calorie dietDIETARY_SUPPLEMENT

low calorie diet

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \> 30 and \< 40 (kg/m2) * Healthy Exclusion Criteria: * Other known illness * Medicine that affects glucose- and lipid metabolism, appetite or food intake * Pregnancy * Breast feeding

Locations (2)

University of Copenhagen

Copenhagen, Denmark

Hvidovre University Hospital

Hvidovre, Denmark

Outcomes

Primary Outcomes

Change in hormone level corrected for weight change

Time frame: Baseline and week 52

Data from ClinicalTrials.gov

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