The purpose of this study is to assess safety and efficacy of Ticagrelor versus Clopidogrel in Asian/KOREAn patients with acute coronary syndromes intended for invasive management.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
800
180mg loading and 90mg bid
600mg loading and 75mg qd
Asan Medical Center
Seoul, Songpa-gu, South Korea
Keimyung University Dongsan Medical Center
Daegu, South Korea
Chungnam National University Hospital
Daejeon, South Korea
Dongguk University Gyeongju Hospital
The time to first occurrence of any bleeding event
Safety of Ticagrelor compared to Clopidogrel by measuring the time to first occurrence of any bleeding event(including major, minor bleedings)
Time frame: 1year
The time to first occurrence of any event from the composite of death from vascular causes, Myocardial Infarction (MI) and stroke
Effect of Ticagrelor compared to Clopidogrel by measuring: time to first occurrence of any event from the composite of death from vascular causes, Myocardial Infarction (MI) and stroke
Time frame: 1year
The time to first occurrence of major bleeding event
by PLAtelet inhibition and patient Outcomes(PLATO) criteria
Time frame: 1year
The time to first occurrence of minor bleeding event
by PLAtelet inhibition and patient Outcomes(PLATO) criteria
Time frame: 1year
The time to first occurrence of major bleeding event or minor bleeding event
The Thrombolysis in Myocardial Infarction (TIMI) bleeding criteria
Time frame: 1year
The time to first occurrence of major bleeding event
The Thrombolysis in Myocardial Infarction (TIMI) bleeding criteria
Time frame: 1year
The time to first occurrence of minor bleeding event
The Thrombolysis in Myocardial Infarction (TIMI) bleeding criteria
Time frame: 1year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Gyeongju, South Korea
Inje University Ilsan Paik Hospital
Ilsan, South Korea
Gachon University Gil Hospital
Incheon, South Korea
ChonBuk National University Hospital
Jeonju, South Korea
Dong-A Medical Center
Pusan, South Korea
Inje University Pusan Paik Hospital
Pusan, South Korea
Ulsan University Hospital
Ulsan, South Korea
The time to first occurrence of Bleeding Academic Research Consortium (BARC) bleeding event from type 1 to type 5
By Bleeding Academic Research Consortium(BARC) Definition of Bleeding Events
Time frame: 1year
The time of first occurrence of discontinuation of study medication from any bleeding event
Time frame: 1year
Non serious adverse events
Time frame: 1year
Adverse events following discontinuation of study medication
Time frame: 1year
Serious adverse events
Time frame: 1year
The time to first occurrence of death from vascular causes
Effect of Ticagrelor compared to Clopidogrel by measuring: time to first occurrence of death from vascular causes
Time frame: 1year
The time to first occurrence of myocardial infarction
Effect of Ticagrelor compared to Clopidogrel by measuring: time to first occurrence of myocardial infarction
Time frame: 1year
The time to first occurrence of stroke
Effect of Ticagrelor compared to Clopidogrel by measuring: time to first occurrence of stroke
Time frame: 1year
The time to occurrence of composite events
The time to occurrence of composite events(death from any cause, myocardial infarction, stroke)
Time frame: 1year
The time to occurrence of death from any cause
Time frame: 1year
Number of patients with net clinical benefit of any total bleeding and any event from the composite of death from vascular causes, Myocardial Infarction and stroke.
Time frame: 1year