The study was conducted to investigate the effect of soluble phosphate in combination with different calcium doses on calcium and phosphorus metabolism and further physiological parameters in healthy subjects. The main aim of the study is to investigate the influence of a soluble phosphate supplementation on the fasting blood phosphate concentration and the dependency of an additional calcium intake.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
62
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1g phosphorus/d\]
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1 g phosphorus/d\] and calcium \[0,5 g calcium\]
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1 g phosphorus/d\] and calcium \[1 g calcium\]
Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Nutritional Toxicology
Jena, Thuringia, Germany
Fasting phosphate concentration in blood
Time frame: 8 weeks
Calcium and phosphorus metabolism
* parameters of phosphate and calcium metabolism (1,25-OHD; 25-OHD;FGF23;PTH) * parameters of bone formation and resorption (osteocalcin, P1NP, CTX) * minerals in plasma, faeces and urine
Time frame: 8 weeks
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all participants consume two weeks before intervention the beverage without phosphate and calcium