Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation

N/AUnknownNCT02095431

University of Sao Paulo122 enrolled

Overview

Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent. We hypothesized that the pattern of novel biomakers elevation could be a prognostic tool to provide information on the risk of progression of AKI, the need for RRT and mortality.

Study Type

OBSERVATIONAL

Enrollment

122

Conditions

Acute Kidney Injury

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Older than 18 years * Reception liver transplantation Exclusion Criteria: * CKD stage 4 / 5 * Combined organ transplants * Patients receiving dialysis before liver transplant operation

Locations (1)

University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Development of Acute Kidney Injury based on novel biomarkers

Compare the timing for diagnosis of AKI comparing novel biomarkers and serum creatinine defined by Kidney Disease Improving Global Outcomes. In addition, we aim to evaluate if the pattern of elevation of the novel biomarkers provide information on progression and severity of AKI.

Time frame: within 7 days

Secondary Outcomes

Short and long term renal outcomes

renal function and need for RRT

Time frame: 1 year

Association of urine chemistry and microscopy to predict acute kidney injury

Association of urine chemistry and microscopy with novel biomarkers to predict AKI diagnosis and progression

Time frame: within 7 days of liver transplantation

Data from ClinicalTrials.gov

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