A pharmacokinetic study to access how the body absorbs and removes ABT-199 in adults with Non-Hodgkin's Lymphoma.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
\[14C\]ABT-199 will be administered as a single oral administration
Maximum observed plasma concentration (Cmax) of ABT-199 and [14C]ABT-199
Time frame: For approximately 9 days following a single oral dose of [14C]ABT-199
Time to Cmax (Tmax) for ABT-199 and [14C]ABT-199
Time frame: For approximately 9 days following a single oral dose of [14C]ABT-199
Area Under the Time curve (AUC) for ABT-199 and [14C]ABT-199
The area under the exposure-time curve from time zero to Day 9 and time zero extrapolated to infinite time for single dose of \[14C\]ABT-199
Time frame: For approximately 9 days following a single oral dose of [14C]ABT-199
Number of subjects with adverse events
Adverse event monitoring, lab test assessment, physical exam and vital signs will be evaluated throughout the study.
Time frame: At each visit (daily for approximately the first 9 days)
Percentage of subjects with adverse events
Adverse event monitoring, lab test assessment, physical exam and vital signs will be evaluated throughout the study.
Time frame: At each visit (daily for approximately the first 9 days)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.