HDL-C in Cardiac Syndrome X

N/ACompletedNCT02095964

Bursa Yuksek Ihtisas Training and Research Hospital710 enrolled

Overview

High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver\[10\]. HDL-C promotes endothelial generation of nitric oxide (NO) and improves endothelial function and arterial vasoreactivity\[11\]. In several studies, lower HDL-C level was reported to be associated with increased coronary artery disease (CAD) risk\[12-14\]. HDL-C also has anti- inflammatory and anti-oxidant activities\[15,16\]. Concerning anti-inflammatory activity, HDL-C inhibits the activation of monocytes/macrophages and neutrophils\[17,18\] and inhibits the expression of endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and E-selectin\[15\]. In this study we aimed to investigate the relation of HDL-C level with systemic inflammatory markers in patients with cardiac syndrome X (CSX).

Study Type

OBSERVATIONAL

Enrollment

710

Conditions

Cardiovascular Diseases Heart Diseases Myocardial Ischaemia Unstable Angina Microvascular Angina

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Must be able to get exercise stress test * Must be able to have coronary angiography * Clinical diagnosis of typical anginaduring rest or effort * Abnormal test result for exercise ECG or myocardial perfusion scintigraphy * Must have of angiographically normal epicardial coronary arteries Exclusion Criteria: * Patients with valvular heart disease (mitral stenosis and moderate to severe mitral regurgitation * Patients with moderate to severe aortic stenosis and regurgitation including mitral annular calcification) * Patients with heart failure (left ventricular ejection fraction \<50%) * Patients with congenital heart disease, cardiomyopathy, left ventricular hypertrophy, right ventricular hypertrophy * Patients with cardiac surgery * Patients with thyroid disease * Patients with anemia * Patients with pulmonary diseases * Patients with infectious diseases (locally or systemic)

Outcomes

Primary Outcomes

HDL-Cholesterol

HDL-Cholesterol \<40 mg/dL(male) / \< 50mg/dL(female) ==\> low HDL-C

Time frame: 6 MONTHS

Cardiac Syndrome X

Patients who have typical anginal chest pain+ischaemic findings at exercise stress test/myocardial scintigraphy + normal epicardial coronaries at coronary angiography ==\> Cardiac syndrome X

Time frame: 6 months

Inflammation

CRP \> 2,98 mg/dL ==\> systemic inflammation

Time frame: 6 months