Prophylactic Antibiotics or Placebo After Hypospadias Repair

Inclusion Criteria: * mid-to-distal shaft hypospadias * single-stage hypospadias repair * length of urethral repair (urethroplasty) less than or equal to 20 mm * placement of an open-drainage urethral stent at the time of hypospadias repair, with intended duration of stenting for 5-10 days post-operatively Exclusion Criteria: * previous hypospadias repair * prior adverse/allergic reaction or other contraindication to trimethoprim-sulfamethoxazole * cross-reactivity of an existing medication with trimethoprim-sulfamethoxazole * any patient condition with elevated risk of infection or adverse outcome from potential infection (e.g., HIV/AIDS, poorly controlled diabetes mellitus or other immunocompromising conditions, congenital heart disease) * use of antibiotics within seven days prior to hypospadias repair * foreskin reconstruction at the time of hypospadias repair * prescription of oral antibiotics other than Study Medication at the time of hypospadias repair