Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

N/ACompletedNCT02096224

Seoul National University Hospital108 enrolled

Overview

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways. We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

108

Conditions

Catheter Site Discomfort Complications Anesthesia Urinary Bladder Neoplasms

Interventions

SevofluraneDRUG

Sevoflurane will be used.

DesfluraneDRUG

Desflurane will be used

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for transurethral bladder excision under general anesthesia * ASA I-III Exclusion Criteria: * Bladder outflow obstruction * Overactive bladder * End-stage renal disease * Neurogenic bladder * Heart failure * Arrhythmia * Morbid obesity * Use of chronic analgesic medication * Hepatic disease * Pulmonary disease * Psychiatric disease

Locations (1)

Seoul National University of Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Catheter-related bladder discomfort

Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

Time frame: 24 hour postoperatively

Secondary Outcomes

Catheter-related bladder discomfort

Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

Time frame: 0, 1, 6 and 24 hour postoperatively

Nausea

The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.

Time frame: 0, 1, 6 and 24 hour postoperatively

Vomiting

The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.

Time frame: 0, 1, 6 and 24 hour postoperatively

Dry mouth

Dry mouth after the admission of operating room will be assessed. (score:0-10)

Time frame: 0 houe after admission of operating room

Data from ClinicalTrials.gov

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