This is a 24-week, one arm, open-label, interventional, non-comparative multicenter study to evaluate lipid changes in HIV infected women with hyperlipidemia on boosted PI based regimen after switching their boosted PI to raltegravir at standard dosage with 400mg twice daily. This study aims to study the effect on metabolic profiles by switching hyperlipidemic HIV infected women from a PI based regimen to raltegravir.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
11
PMU Salzburg
Salzburg, Austria
AKH Wien
Vienna, Austria
Ottto Wagner Spital
Vienna, Austria
Patients With Low-density Lipoprotein (LDL) Cholesterol Reduction
A reduction of \> 5% in the plasma concentration of direct LDL cholesterol from baseline to week 12 or \> 10% reduction of total cholesterol or reduction of lipid lowering agents is expected. Reduction of lipid lowering agents is defined as reduction due to amelioration of lipid profiles and does not include reduction due to side effects or other toxicity issues.
Time frame: baseline to week 12
Total Cholesterol Baseline and After 24 Weeks
Time frame: baseline to week 24
Triglycerides Baseline and After 24 Weeks
Time frame: baseline to week 24
High-density Lipoprotein (HDL) Cholesterol Baseline and After 24 Weeks
Time frame: baseline to week 24
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