Impact of the Fecal Flora Transplantation on Crohn's Disease

Receiver Inclusion Criteria: * Age \> 18 years and \< 70 years * Crohn's disease with colonic or ileo-colonic involvement * Active disease at screening defined by a Harvey Bradshaw Index \>4 * Clinical remission (Harvey Bradshaw Index \<5) in the 3 weeks following corticosteroid onset * Patient with health insurance * Written consent obtained Exclusion Criteria: * Fistulizing disease * Anoperineal or abdominal abscess * Complication requiring surgical treatment * Treatment with anti-TNFa (ongoing or stopped in the 1 month preceding randomization) * Immunosuppressant treatment started or stopped in the 3 months preceding randomization * Non-steroidal anti inflammatory drugs (NSAIDs) intake in the 4 weeks preceding randomization * Antibiotics or antifungic treatment in the 4 weeks preceding colonoscopy * Probiotics intake in the 4 weeks preceding colonoscopy * Clostridium difficile infection in the 10 days preceding randomization * contraindication to colonoscopy or anesthesia * Pregnancy Donor Inclusion Criteria: * Age \> 20 years and \< 50 years * 27kg/m² \> BMI \> 17 kg/m² * Regular bowel movement with usually one bowel movement in the morning * Subject with health insurance * Written consent obtained Exclusion Criteria: * Infection risk: * Known infection by human immunodeficiency virus (HIV), Human T Leukemia Virus (HTLV), Hepatitis B or C virus. * At risk behavior: Travel (in the preceding 3 months, excepting in Euro area, United Kingdom, Bulgaria, Poland, Romania, Croatia, Hungary, Republic Tcheque, Denmark, Norway, Sweden, Swiss, USA or Canada), at risk sexual activity (intercourse without protection with a new partner) in the preceding 6 months, blood transfusion, piercing or tattoo in the preceding 6 months residence of several years in intertropical area, abroad hospitalization more than 24 hours in the last 12 months (including patient and his immediate family). * Positive result at one of the screening tests for infectious disease. : HIV, HCV, HBV, HTLV, syphilis, Enteric viruses (Rotavirus, HEV, Adenovirus, Norovirus, Enterovirus, HAV, Poliovirus, Astrovirus, Aichi virus, Sapovirus), parasites in stool (Cyclospora, Isospora, Cryptosporidium, Microsporidium, Strongyloides stercoralis, Entamoeba histolitica, Giardia intestinalis, Dientamoeba fragilis), and in blood (Strongyloides stercoralis, Trichinella spiralis, Amoebiasis), pathogenic bacteria in stool (Clostridium difficile, Shigella, Campylobacter, Yersinia, Salmonella, Listeria monocytogenes, Vibrio cholerae/parahemolyticus, verotoxin-producing E. coli) * Anal lesions suggesting viral infection or positive test for HSV anal and/or multi-drug resistant bacteria (Enterobacteria producing extended spectrum betalactamase, Actinobacter baumanii, Vancomycin resistant enterococci and carbapenemase producing bacteria). * Positive test for multidrug resistant bacteria * If receiver is EBV negative, EBV positive donor will be excluded * If receiver is CMV negative, CMV positive donor will be excluded. * If receiver is negative for Toxoplasma gondii, positive donor for Toxoplasma gondii will be excluded * Known transmissible infectious disease * Infection (or possible infection) in the 7 days preceding screening * Risk factors for Creutzfeldt-Jakob disease * Personal history of Typhoid fever * Gastrointestinal comorbidity * Personal history or first degree relative : * Inflammatory bowel disease * Coeliac disease * Personal history of irritable bowel syndrome, chronic constipation, chronic diarrhea * Personal history of gastrointestinal neoplasia or polyposis * First degree relative with gastrointestinal neoplasia or polyposis before 60 years old * Gastrointestinal infection in the 3 preceding months (defined by the occurrence of an acute diarrhea that last less than a week) * Factors possibly affecting the composition of the microbiota: * Antibiotics or antifungic intake in the 3 preceding months before FT * Non-steroidal anti inflammatory drugs (NSAIDs) intake in the 4 weeks preceding FT * Specific diet (exclusion diet, vegetarian diet) * Pregnancy * Immunosuppressant intake (corticosteroids, calcineurin inhibitors, biologics, etc) * Anti neoplastic chemotherapy * Hemorrhoid disease * Personal history or first degree relative with inflammatory or autoimmune disease * Other Factors : * Known chronic disease * Abnormality at initial biological check up: blood cells count, fasting, glycaemia, kidney function, liver tests, haemostasis, calprotectin * Long term curative therapy * Recent intake of food allergens related of receiver's known allergy * between screening and FT : * At risk behavior (Travel, at risk sexual activity, blood transfusion, piercing tattoo, accidental blood exposure) * Anal lesions suggestive of viral infection or positivity for HSV in anal area * Infection or possible infection * Occurrence of gastro-intestinal symptoms * Medicine intake in the 48 hours preceding FT (except contraceptive) * In case of woman: menstruation in the 48 hours preceding FT