Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™

Inclusion Criteria: * Functional symptomatic tricuspid regurgitation (TR) 2+ to 4+ on a scale of 4+ (moderate to severe), with annular dilatation greater than 40mm. * Signed informed consent form prior to any study-related procedure. * Available and able to return to the study site for post-procedural follow-up examination * Eighteen (18) years of age or older. Exclusion Criteria: * Requirement for concomitant cardiac procedure (other than atrial fibrillation correction surgery, closure of PFO (Patent Foramen Ovale) or ASD (Atrial Septal Defect), or PTCA (percutaneous treatment of coronary artery) or CAD (coronary artery bypass surgery) from 1 to 3 months after or before other procedure. * Presence of any known life threatening (non-cardiac major or progressive disease), non-cardiac disease that will limit the subject's life expectancy to less than one year. * Cerebro-vascular event within the past 6 months. * History of mitral/tricuspid endocarditis within the last 12 months. * Organic tricuspid disease. * Contraindication or known allergy to device's components, aspirin, anti-coagulation therapy or contrast media that cannot be adequately premeditated. * Severe hypertension (SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg, measurement done by sphygmomanometer with stethoscope, allow the patient to sit for at least 5 minutes before beginning BP measurements). * Female patient is pregnant (urine HCG test result positive) or lactating. * Known alcohol or drug abuser. * Currently participating in the study of an investigational drug or device. * At heart team's judgement, patient IVC dimension is not adequate for device implantation.